Yes, it often does. The brain may be affected secondarily, by way of opportunistic infections invading the brain in immunosupressed individuals; and primarily, by way of HIV’s direct impact on the brain. This will result in “HIV encephalopathy” and even in “HIV dementia.” So it is important to pay attention to any cognitive changes in people with HIV. Fortunately, more recent HIV drugs are reasonably good at crossing the “bllod-brain” barrier; as the result both the incidence and severity of cognitive impairment in HIV has declined.
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